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Dimethyl Isosorbide (DMI) Ultimate Penetration Enhancer for Skincare Actives
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Product Description
Dimethyl Isosorbide (DMI) is an eco-friendly solvent synthesized from renewable sorbitol, with the chemical name dimethyl isosorbide. Its molecular structure, containing two methoxy groups and a furan ring, endows it with excellent solubility and stability. As a colorless, transparent liquid, DMI is miscible with water, polyols, and esters in any proportion, maintaining liquid fluidity within the temperature range of -50°C to 200°C. It creates permeation channels by dissolving free fats on the skin’s surface, aiding active ingredients in penetrating the stratum corneum. It is non-irritating to the skin, with safety validated by multiple toxicological studies.
Unlock the full potential of your active ingredients with Aogebio® Dimethyl Isosorbide (DMI), the gold-standard penetration enhancer trusted by cosmetic chemists and skincare brands worldwide. Our pharmaceutical-grade DMI significantly improves the delivery and efficacy of skincare formulations by:
✔ Boosting active ingredient absorption – Enhances transdermal penetration by up to 300%
✔ Solubilizing challenging compounds – Perfect for vitamin C, retinoids, and CBD formulations
✔ Maintaining lightweight texture – Non-greasy alternative to silicones and oils
✔ Improving formula stability – Extends shelf life of oxidation-prone actives
Why Formulators Choose Aogebio® DMI:
→ 99.9% Purity: Highest grade available for cosmetic applications
→ Multi-Functional: Acts as solvent, carrier, and penetration booster
→ Safety Certified: Non-irritating (OECD 439 tested) and vegan
→ Versatile Compatibility: Works in serums, creams, and transdermal systems
High-Efficiency Solvent and Carrier
DMI exhibits excellent solubility for both polar and non-polar ingredients, dissolving poorly soluble actives like salicylic acid, vitamins, and resorcinol-based whitening agents, ensuring their uniform dispersion and stability in formulations.
Enhanced Transdermal Absorption
By disrupting the ordered arrangement of lipid structures in the stratum corneum, DMI significantly improves the transdermal efficiency of active ingredients. Studies show it can increase the transdermal delivery of diazepam several times over, and in cosmetics, it is often used to enhance the skin penetration of anti-aging and spot-lightening ingredients.
Support for Formulation Stability
DMI is resistant to high temperatures and chemically stable, preventing formulations from undergoing hydrolysis, oxidation, or other reactions during storage or exposure to heat.
Gentle and Low-Irritation
Compared to traditional penetration enhancers, DMI is less irritating to the skin, making it suitable for sensitive skin formulations. Its thiol-containing components also help neutralize free radicals, aiding in antioxidant protection.
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Use
Typically added at 1-10% in cosmetic formulations, depending on specific needs. For example, 3-5% is used in whitening serums to boost niacinamide penetration, while 2-4% is included in sunscreen lotions to dissolve sunscreens.
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Skincare Products
Used in serums targeting chloasma and sun spots to accelerate melanin metabolism.
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Anti-Aging Products
Included in creams containing peptides or pro-Xylane to promote ingredient penetration into the dermis, stimulating collagen production.
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Color Cosmetics
Acts as a dispersant in liquid foundations for a smooth, skin-adhering finish. Aids film-forming agents in setting sprays for long-lasting wear.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available